Control of gene expression
| Nature | Unknown label |
|---|
| Credit hour | 3 |
|---|---|
| Total number of hours | 30 |
| Number of hours for lectures | 18 |
| Number of hours for tutorials | 12 |
Prerequisites
Basic knowledge of molecular biology and genetics
Goals
Knowledge of the main mechanisms of regulation of gene expression: transcriptional, post-transcriptional, translational and post-translational regulation mechanisms.
Content
Lectures:
• Transcriptional control: eukaryotic transcription, transcription factors and their mode of action, chromatin and gene expression, euchromatic boundary regions, methylation and gene expression.
• Post-transcriptional control at the mRNA level: message stability, regulation by alternative splicing, editing.
• Translational control: external and internal initiation mechanisms, regulatory strategies.
• Post-translational control: protein conformation control, protein modification, protein localization, protein degradation.
Tutorials:
• Analysis of scientific articles related to the course, with student presentations.
• Transcriptional control: eukaryotic transcription, transcription factors and their mode of action, chromatin and gene expression, euchromatic boundary regions, methylation and gene expression.
• Post-transcriptional control at the mRNA level: message stability, regulation by alternative splicing, editing.
• Translational control: external and internal initiation mechanisms, regulatory strategies.
• Post-translational control: protein conformation control, protein modification, protein localization, protein degradation.
Tutorials:
• Analysis of scientific articles related to the course, with student presentations.
Additional Information
Knowledge of the main mechanisms of regulation of gene expression: transcriptional, post-transcriptional, translational and post-translational regulation mechanisms.