Nature Unknown label
Credit hour 3
Total number of hours 29
Number of hours for lectures 13
Number of hours for tutorials 12
Number of hours for laboratory work 4

Prerequisites

Basic knowledge in genetics.

Goals

• Understand the major epigenetic mechanisms involved in genome expression regulation.

Content

Lectures (13.5h):
Topics include:
• DNA methylation.
• Histone modifications and histone variants.
• Chromatin remodeling.
• Small non-coding RNAs.
• Nuclear architecture.
These theoretical concepts will be illustrated with examples of epigenetic regulation such as X-chromosome inactivation, genomic imprinting in mammals, and regulation of transposable elements in Drosophila and plants, presented during mini-conferences by researchers.
Tutorials (12h):
Analysis and presentation of scientific articles by students, including methodological aspects of epigenome studies.
Practical Sessions (4.5h):
Analysis of epigenomic datasets such as ChIP-Seq, methylome, or 4C.

Additional Information

• Understand the major epigenetic mechanisms involved in genome expression regulation.