Epigenetic Regulations
| Nature | Unknown label |
|---|
| Credit hour | 3 |
|---|---|
| Total number of hours | 29 |
| Number of hours for lectures | 13 |
| Number of hours for tutorials | 12 |
| Number of hours for laboratory work | 4 |
Prerequisites
Basic knowledge in genetics.
Goals
• Understand the major epigenetic mechanisms involved in genome expression regulation.
Content
Lectures (13.5h):
Topics include:
• DNA methylation.
• Histone modifications and histone variants.
• Chromatin remodeling.
• Small non-coding RNAs.
• Nuclear architecture.
These theoretical concepts will be illustrated with examples of epigenetic regulation such as X-chromosome inactivation, genomic imprinting in mammals, and regulation of transposable elements in Drosophila and plants, presented during mini-conferences by researchers.
Tutorials (12h):
Analysis and presentation of scientific articles by students, including methodological aspects of epigenome studies.
Practical Sessions (4.5h):
Analysis of epigenomic datasets such as ChIP-Seq, methylome, or 4C.
Topics include:
• DNA methylation.
• Histone modifications and histone variants.
• Chromatin remodeling.
• Small non-coding RNAs.
• Nuclear architecture.
These theoretical concepts will be illustrated with examples of epigenetic regulation such as X-chromosome inactivation, genomic imprinting in mammals, and regulation of transposable elements in Drosophila and plants, presented during mini-conferences by researchers.
Tutorials (12h):
Analysis and presentation of scientific articles by students, including methodological aspects of epigenome studies.
Practical Sessions (4.5h):
Analysis of epigenomic datasets such as ChIP-Seq, methylome, or 4C.
Additional Information
• Understand the major epigenetic mechanisms involved in genome expression regulation.